The blast took place 6:30 a.m. local time.
State television quoted witnesses as saying gunmen opened fire on buildings after the blast.
Bombings and shootings targeting security forces have become commonplace since Islamist President Mohammed Mursi was deposed by the army last July after mass protests against his rule.
On Thursday, masked gunmen riding motorcycles killed five Egyptian policemen in an attack on a checkpoint south of the capital Cairo, the Interior Ministry said.
The attack in the province of Beni Suef also wounded two policemen, and came two days ahead of the third anniversary of the 2011 uprising.
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