The broad-based S&P 500 dipped 2.13 points, or 0.11 per cent, to 1,909.78, snapping a two day streak of record closes.
The tech-rich Nasdaq Composite Index lost 11.99 points, or 0.28 per cent, to 4,225.08.
European stocks mostly rose, but Frankfurt retreated from the key 10,000-points barrier following disappointing unemployment data.
Frankfurt's DAX 30 index of top shares slipped 0.02 per cent to 9,939.17 points from Tuesday's record closing level, having risen as high as 9,957.87 during trading on Wednesday.
London's FTSE 100 index of top companies added 0.09 per cent to 6,851.22 points, and after spending much of the afternoon in the red the CAC 40 in Paris eked out a gain of 0.04 per cent to close at its highest point this year at 4,531.63 points.