At least three people were killed and seven wounded on Monday in an explosion at a hotel in southeast Afghanistan's Khost province, the province's media office said, APA reports citing Reuters.
The cause of the blast was not immediately clear though the region, near the border with Pakistan, has long been plagued by violence between Islamist militants and their enemies.
The Khost media office said people originally from Pakistan's Waziristan region, which is just over the border and where for years various militant groups have operated, were among the casualties.
Pakistan's foreign office did not immediately respond to a request for comment.
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Casualties are feared as a blast shocked the eastern Afghanistan city of Khost on Monday, provincial police spokesman Mustaghfar Garbaz said, APA reports citing Xinhua News.
There is still no information about the casualties.