At an event at the Harvard University, the top U.S. diplomat said he would go to the region "at some point appropriately," without announcing a date, to move the situation away from "precipice".
"What's happening is that, unless we get going, a two-state solution could conceivably be stolen from everybody," Kerry said. "You have this violence because there's a frustration that is growing and a frustration among Israelis who don't see any movement."
Three Israelis were killed and at least 15 others wounded in a series of attacks in Jerusalem and central Israel on Tuesday, in the gravest outbreak of Palestinian violence since the current round of unrest started.
The recent violence broke out last month with clashes at East Jerusalem's flashpoint al-Aqsa mosque compound and quickly spread throughout the West Bank and the Gaza Strip.
Earlier in the day, at a press conference held in Boston after the annual Australia-U.S. Ministerial Consultations, Kerry said the U.S. condemns "in the strongest terms possible" the terrorist attacks against Israeli civilians.
"The situation is simply too volatile, too dangerous, and it is not going to lead to the outcome that people want, which is to have a peaceful resolution of the differences," Kerry said.
At a regular press briefing on Tuesday, White House spokesman Josh Earnest reiterated the U.S. policy of seeking a two-state solution to the Israeli-Palestinian conflict, saying it is "the most effective way" to address the issue.