The factory sits in an industrial park at Ciudad Juarez, a large city on the U.S. border, and firefighters said they were still trying to put out the flames.
"It was a bad explosion," said Guillermo Terrazas, a local government spokesman in Ciudad Juarez, adding it was unclear if anyone had been killed or was trapped under debris in the building.
An emergency services official said 30 people were injured, 11 of them badly with five in intensive care.
A second official said, speaking on condition of anonymity, that around 20 people who work at the plant were unaccounted for. It was unclear if they were in the building at the time.
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