The comments appeared to contradict more moderate president Hassan Rouhani, who said on Tuesday the Islamic Republic was ready to hold talks with the United States on ways to resolve Syria's civil war.
"We negotiated with the U.S. on the nuclear issue for specific reasons. (The Americans) behaved well in the talks, but we didn't and we won't allow negotiation with the Americans on other issues," Ayatollah Khamenei was quoted as saying.